Is a flexible spatial-omics platform enabling spatial transcriptomics and/or spatial proteomics in user-selected regions of interest. Combine the best of spatial and molecular profiling technologies by spatially profiling digital whole transcriptomes, cancer transcriptomes and profiling data for 100s of validated protein analytes.
Reliably and quantitatively assess the heterogeneity within your tissue samples with a combination of the most flexible, nondestructive, and robust high-plex and high-throughput spatial spatial solution.
Traditionally, researchers must choose between morphological analysis or high-plex, which forfeits important information or squanders prized samples. Sample data may be compromised by other cells that do not originate from the target tissue that researchers are profiling, so understanding tissue heterogeneity is critical to answering any biological questions.
NanoString DSP combines In Situ Visualization with Molecular Profiling Technologies to get the best of both worlds.
Harness high-resolution, spatially resolved molecular data from tissue samples with NanoString’s step-by-step workflow:
Begin by sectioning formalin-fixed, paraffin-embedded (FFPE) or fresh frozen tissue samples. Mount the sections onto slides compatible with the GeoMx DSP system.
Apply fluorescently labeled antibodies or RNA probes to the tissue sections. These morphology markers help visualize tissue architecture and identify regions of interest (ROIs).
Capture high-resolution images of the stained tissue sections. Using these images, define and select specific regions of interest based on morphological features.
Illuminate the selected ROIs with UV light to release photocleavable oligonucleotide barcodes linked to the probes. Collect these released barcodes for further molecular analysis.
Perform next-generation sequencing (NGS) on the collected barcodes to quantify the expression levels of target proteins or RNAs within each ROI.
Process the sequencing data using specialized software that aligns it with the spatial information from the tissue sections. Generate spatial expression maps to visualize molecular distribution within the tissue.
Analyze the spatial expression patterns to gain insights into tissue architecture, cellular interactions, and disease mechanisms. Use these findings to advance research in fields such as oncology, immunology, and neuroscience.
Our offer of the Nanostring DSP comes with access to an array of data atlases and analysis models:
Unlock new insights in oncology, immunology, neuroscience, and developmental biology with the GeoMx Human Whole Transcriptome Atlas (WTA). This cutting-edge solution enables comprehensive transcriptomic profiling, providing an unparalleled view into gene expression at spatial resolution. With over 18,000 human and 21,000 mouse targets, researchers can break barriers in disease research, biomarker discovery, and therapeutic development.
Gain a comprehensive view of tumor biology, the immune response, and the tumor microenvironment with the GeoMx® Cancer Transcriptome Atlas (CTA). Designed for all-inclusive cancer profiling, CTA enables high-resolution spatial transcriptomics by targeting an impressive 1,800+ RNA markers across 112 key pathways. It incorporates clinically relevant gene sets, such as BC 360 & IO 360, to accelerate biomarker discovery and deepen insights into cancer progression and treatment response.
Mouse Model Whole Transcriptome Atlas (WTA):
Unlock deeper insights into developmental biology, disease progression, and treatment with comprehensive whole transcriptome analysis across all mouse strains. With exceptional sensitivity and specificity, the GeoMx® Mouse Model WTA enables precise gene detection across diverse expression ranges. Adaptable slide technology supports multiple tissue types, allowing researchers to study functionally unique structures and cell types with unparalleled detail.
Break free from the limitations of traditional immunohistochemistry with GeoMx DSP’s high-plex spatial proteomic analysis. Profile 96+ proteins simultaneously using NGS-validated assays, eliminating the need for extensive troubleshooting. With flexible modular designs for human and mouse proteins, researchers can analyze dozens to hundreds of targets in a single tissue section with precision and efficiency.
Streamline data discovery, visualization, and analysis with the GeoMx® DSP data suite—an end-to-end solution for efficient workflow management. From image tracking to advanced statistical analysis, researchers gain powerful tools for segmentation, quality control, and publication-ready visualizations. With expert consulting from BioChain’s digital multiomics scientists, effortlessly detect group differences, automate ROI selection, and explore whole tissue sections at single-cell resolution.
Reach out to us to customize your project! We offer a fully customizable, end-to-end, full stack process able to conform to your needs.
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