Single Cell and Spatial Insight:
One Partner. Zero Compromise.
Unify single-cell and spatial insight today.
Elite biospecimen sourcing. Specialized histopathology. Deep multi-omic integration. BioChain is the high-fidelity partner that empowers you to bridge the gap between cellular identity and tissue context with absolute certainty.
DISCOVER
Chromium Single Cell
10x Genomics Chromium isolates and profiles gene expression signatures of individual cell types and states within your tissue sample. Generate high resolution reference sets for an informed analysis of spatial data with the help of BioChain’s in-house experts.
What’s Included:
- Full scope of Chromium assay options
- High-throughput digital counting of mRNA (3’ and 5’ Gene Expression)
- Full-length V(D)J sequencing for BCR/TCR repertoire analysis
- ATAC-seq to uncover the regulatory landscape of individual cells
- CITE-seq simultaneous detection of RNA and 100+ surface proteins
Download the BioChain Spatial Guide
Discover
Chromium Single Cell
10x Genomics Chromium isolates and profiles gene expression signatures of individual cell types and states within your tissue sample. Generate high resolution reference sets for an informed analysis of spatial data with the help of BioChain’s in-house experts.
What’s Included:
- Full scope of Chromium assay options
- High-throughput digital counting of mRNA (3’ and 5’ Gene Expression).
- Full-length V(D)J sequencing for BCR/TCR repertoire analysis.
- ATAC-seq to uncover the regulatory landscape of individual cells.
- CITE-seq simultaneous detection of RNA and 100+ surface proteins for granular phenotyping.
Localize, Validate
Use pathologist guided insight to analyze 10x Visium HD and Xenium in-situ data.
No more middle man. Our in-house, MD-guided histopathology and TMA construction capabilities ensure that every assay run is translated into something publication-ready and QC-checked from before analysis even begins.
Apply
From data delivery to strategic discovery.
An easy 3-step process:
- Computationally integrated data objects (Seurat/AnnData) that map single-cell resolution directly to spatial context
- Experience a seamless starting point
- Accelerate the path to target validation or biomarker discovery
What You're Looking For
The Power of Unified Discovery
From high-failure-risk samples to IND-enabling data, BioChain delivers the integrated insights that accelerate your path to discovery. Stop coordinating fragmented data. Start answering your most complex biological questions with a single, ISO-certified partner.
Your Vision - Accelerated
Strategic decision-making in drug development fails when data is siloed. Relying on a single modality creates dangerous blind spots and stalls a research pipeline for months.
BioChain bridges the gap.
We have integrated Chromium Single Cell resolution with Visium HD and Xenium In Situ context to provide the industry’s most robust, end-to-end ecosystem. We optimize the entire workflow—Single Cell to Spatial to Final Data—to turn raw biological noise into decision-ready intelligence.
Master Spatial Complexity.
Many labs can run a spatial assay; BioChain specializes in executing complex, high-risk-of-failure projects.
We are the strategic partner of choice for biopharma and academic segments that require sophisticated spatial insights and want to avoid the prohibitive risk of siloed or single-speciality partner infrastructure.
Sample Mastery
Whether you provide archived FFPE, low-input clinical specimens, or require our in-house sourced tissue, we execute with confidence. No matter how difficult the sample is, BioChain has optimized for it already.
Regulatory Readiness
Our workflows are supported by standardized SOPs and audit trails specifically engineered to withstand the scrutiny of IND-enabling projects. Experience:
- Archival & Custom FFPE Specialists: Extract high-parameter data from custom sourced and archived FFPE samples that frequently defeat less specialized providers.
- Precision From The Source: As a world leader in biospecimen procurement, we control the most volatile variable: the sample. Our fresh tissue (<1 hr ischemic time) and flash-frozen SOPs ensure your data isn’t compromised by transcriptional stress or degradation.
- Regulatory Readiness: ISO 9001 and ISO 13485 certified workflows, specifically engineered with the audit trails and documentation required to withstand the scrutiny of IND pipeline projects.
BioChain operates under a sophisticated data protection policy and strict GDPR-compliant protocols, providing an ironclad foundation of security for your proprietary multi-omic data.
Full Service Discovery, Customized
The BioChain Multi-Omic Suite: Three Modalities. One Strategic Answer.
Positioned at the junction of cellular resolution and tissue context, BioChain is one of the only CROs with whom you can extend a single cell study into spatial multiomics on the same samples, with the same team, through one single unified workflow.
| Your Objective | Our Solution | Technical Empowerment |
|---|---|---|
| Discover | 10x Genomics Chromium Single Cell | Capture 20,000+ genes to identify rare cell populations and novel states that spatial-only tools miss. |
| Localize | 10x Genomics Visium HD with Cytassist and Visium HD 3’ | Map whole-transcriptome signatures onto tissue architecture at subcellular 2 µm resolution; experience a continuous lawn of 2 µm × 2 µm barcoded squares for long reads and any species. |
| Validate | 10x Genomics Xenium Analyzer | Subcellular spatial imaging of up to 5,000 targeted genes with multiplexed protein co-detection; experience multiomics, transcriptomics and proteomics on the same slide. |
The BioChain Advantage
Precision Starts with Tissue
The success of any single-cell or spatial run is decided before the sample hits the chip. Whether you bring your own samples or use ours, we apply the same world-class mastery to ensure your data isn’t compromised by high-stress dissociation or long ischemic times.
| Service | Technical Specification | Application |
|---|---|---|
| User or In-House Samples | Expertise in archived FFPE and low-input specimens | High-confidence results for even the most difficult tissues. |
| Fresh/Frozen Capability | <1 hr ischemic time; shipped within 24–48 hrs | Preserves native RNA/DNA/Protein for 3D models or proteomics. |
| Blood-Based Biofluids | Plasma, serum, PBMCs, leukopaks, and isolated lymphocytes (T, B, NK). | Robust genomic and proteomic insights from non-invasive samples. |
| Pathology QC | In-house histopathology and TMA construction | Eliminates outsourcing delays; ensures publication-ready results. |
| Final Data Output | Standardized Seurat or AnnData objects | Ready-to-use files that map resolution to context for your team. |
Applications
Powering research across oncology, immunology, neuroscience, and beyond.
BioChain’s single cell services support the research questions driving drug discovery, translational science, and clinical biomarker development.
Immuno-Oncology & TME
Resolve immune infiltration, exhaustion states, and tumor-immune crosstalk at single cell resolution. Identify candidate biomarkers for immunotherapy.
Biomarker Discovery
Discover novel markers with unbiased transcriptomic profiling. Characterize expression across cell types and states to build a biological rationale for appropriate candidates.
Cell & Gene Therapy
Characterize manufacturing intermediates, assess off-target expression, and profile therapeutic cell populations with the resolution needed to support IND-enabling studies and regulatory filings.
Neuroscience & Brain Atlasing
Profile neuronal and glial diversity at single cell resolution. Map cell-type-specific expression across brain regions for disease modeling, target identification, and atlas construction.
Immune Repertoire Analysis
Pair full-length TCR/BCR profiling with gene expression to track clonal expansion, receptor diversity, and treatment response in immunotherapy, vaccine, and autoimmune studies.
Multi-Omic Integration
Combine transcriptomics with ATAC-seq, surface proteins (CITE-seq), or immune receptor sequencing (V(D)J) in a single study. One team manages the complexity so you focus on interpretation.
Experience Matters.
Years of mastery in high-plex biology means we’ve solved the problems others are still discovering. We don’t settle for partial solutions, and neither should your research.